English
norskBlar i forfatter "Hansen, Ann Kristin"
Viser treff 1-17 av 17
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Antibiotic-loaded bone cement in prevention of periprosthetic joint infections in primary total knee arthroplasty: A register-based multicentre randomised controlled non-inferiority trial (ALBA trial)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-28)<i>Introduction</i> - The current evidence on the efficacy of antibiotic-loaded bone cement (ALBC) in reducing the risk of periprosthetic joint infections (PJI) after primary joint reconstruction is insufficient. In several European countries, the use of ALBC is routine practice unlike in the USA where ALBC use is not approved in low-risk patients. Therefore, we designed a double-blinded pragmatic ... -
Biology of signalling receptors in human articular chondrocytes. Implications for chondrogenesis and cartilage repair.
(Doctoral thesis; Doktorgradsavhandling, 2017-12-05)Articular cartilage is the thin avascular tissue covering the ends of adjacent bones that provides frictionless movement to the skeleton. Cartilage injuries are frequent, but due to its avascular nature the cartilage of skeletally matured individuals has a poor healing capacity. Degenerative diseases such as osteoarthritis (OA), is characterised by the gradual destruction of articular cartilage, ... -
Co-expression of 1α-hydroxylase and vitamin D receptor in human articular chondrocytes
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-06)Background: <br> The aim was to investigate whether resident chondrocytes in human articular cartilage and in subculture express vitamin D receptor (VDR) and the enzyme that hydroxylates the prohormone 25(OH)D3 to the active hormone 1α,25(OH)2D3, namely 1α-hydroxylase (CYP27B1). Any putative effects of vitamin D on chondrocytes were also explored. <br> Methods: <br> Cartilage from human osteoarthritic ... -
Collagen-covered autologous chondrocyte implantation versus autologous matrix-induced chondrogenesis: A randomized trial comparing 2 methods for repair of cartilage defects of the knee
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-17)<i>Background</i>: Autologous matrix-induced chondrogenesis (AMIC) is a single-stage alternative to autologous chondrocyte implantation for treatment of localized cartilage defects of the knee. To our knowledge, no randomized controlled trial exists comparing the 2 methods.<p><p> <i>Purpose</i>: To evaluate any difference in the outcome of AMIC as compared with collagen-covered autologous chondrocyte ... -
Cortical bone structure of the proximal femur and incident fractures
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-04)Purpose: Fracture risk is most frequently assessed using Dual X-ray absorptiometry to measure areal bone mineral density (aBMD) and using the Fracture Risk Assessment Tool (FRAX). However, these approaches have limitations and additional bone measurements may enhance the predictive ability of these existing tools. Increased cortical porosity has been associated with incident fracture in some ... -
Determinants of trabecular bone score and prevalent vertebral fractures in women with fragility fractures: a cross-sectional sub-study of NoFRACT
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-21)<i>Summary</i> - Determinants of trabecular bone score (TBS) and vertebral fractures assessed semiquantitatively (SQ1–SQ3) were studied in 496 women with fragility fractures. TBS was associated with age, parental hip fracture, alcohol intake and BMD, not SQ1–SQ3 fractures. SQ1–SQ3 fractures were associated with age, prior fractures, and lumbar spine BMD, but not TBS.<p><p> <i>Introduction</i> ... -
Dynamic expression of VDR and 1-alpha-hydroxylase in differentiated and re-differentiated human articular chondrocytes
(Conference object; Konferansebidrag, 2016-09)<p><i>Purpose:</i> The goal was to investigate potential roles played by vitamin D in the regulation of joint cartilage biology. We studied the expression of two central elements of vitamin D metabolism, namely the vitamin D receptor and its converting enzyme 1αhydroxylase in human knee cartilage and chondrocytes. <p><i>Methods and Materials:</i> Expression of receptor and enzyme was determined ... -
Expression and function of Leukotriene B4 receptors in human articular chondrocytes
(Conference object; Konferansebidrag, 2013)Leukotriene B4 (LTB4) is linked to osteoarthritis (OA) development however the expression of LTB4 receptors in cartilage cells and the physiological effects of LTB4 on cartilage tissue remain unknown. In this study we find that human articular chondrocytes express LTB4 receptors and that these receptors are functional, however, LTB4 does not seem to affect importantly some primary chondrocyte functions. -
High prevalence of vertebral fractures and low trabecular bone score in patients with fragility fractures: A cross-sectional sub-study of NoFRACT
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-08)<p><i>Purpose - </i>Norway has among the highest incidence rates of fractures in the world. Vertebral fracture assessment (VFA) and trabecular bone score (TBS) provide information about fracture risk, but their importance have not been studied in Norwegian patients with fragility fractures. The objectives of this study were to examine the clinical characteristics of a cohort of women and men with ... -
Human articular chondrocytes express functional Leukotriene B4 receptors
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-02-09)Leukotriene B<sub>4</sub> (LTB<sub>4</sub>) is a potent chemoattractant associated with the development of osteoarthritis (OA), while its receptors BLT1 and BLT2 have been found in synovium and subchondral bone. In this study, we have investigated whether these receptors are also expressed by human cartilage cells and their potential effects on cartilage cells. The expression of LTB<sub>4</sub> ... -
In vitro chondrogenic potency of surplus chondrocytes from autologous transplantation procedures does not predict short-term clinical outcomes
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-10)<p><i>Background</i>: Autologous chondrocyte implantation (ACI) has been used over the last two decades to treat focal cartilage lesions aiming to delay or prevent the onset of osteoarthritis; however, some patients do not respond adequately to the procedure. A number of biomarkers that can forecast the clinical potency of the cells have been proposed, but evidence for the relationship between in ... -
Is There a Causal Relationship between Physical Activity and Bone Microarchitecture? A Study of Adult Female Twin Pairs
(Journal article; Tidsskriftartikkel, 2023-05-17)The reasons for the association between physical activity (PA) and bone microarchitecture traits are unclear. We examined whether these associations were consistent with causation and/or with shared familial factors using a cross-sectional study of 47 dizygotic and 93 monozygotic female twin pairs aged 31–77 years. Images of the nondominant distal tibia were obtained using high-resolutionperipheral ... -
Mesenchymal stromal cells from human umbilical cords display poor chondrogenic potential in scaffold-free three dimensional cultures
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-05-27)Many researchers world over are currently investigating the suitability of stromal cells harvested from foetal tissues for allogeneic cell transplantation therapies or for tissue engineering purposes. In this study, we have investigated the chondrogenic potential of mesenchymal stromal cells (MSCs) isolated from whole sections of human umbilical cord or mixed cord (UCSCs-MC), and compared them with ... -
Post-Fracture Risk Assessment: Target The Centrally Sited Fractures First! A Sub-Study of NoFRACT
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-16)The location of osteoporotic fragility fractures adds crucial information to post‐fracture risk estimation. Triaging patients according to fracture site for secondary fracture prevention can therefore be of interest to prioritize patients considering the high imminent fracture risk. The objectives of this cross‐sectional study were therefore to explore potential differences between central (vertebral, ... -
Use of complementary and alternative treatment among recipients of social benefits related to illness.
(Master thesis; Mastergradsoppgave, 2004) -
Validation of forearm fracture diagnoses in administrative patient registers
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-24)Summary The validity of forearm fracture diagnoses recorded in fve Norwegian hospitals was investigated using image reports and medical records as gold standard. A relatively high completeness and correctness of the diagnoses was found. Algorithms used to defne forearm fractures in administrative data should depend on study purpose.<p> <p>Purpose In Norway, forearm fractures are routinely recorded ... -
Validation of forearm fracture diagnoses in administrative patient registers
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-24)Summary The validity of forearm fracture diagnoses recorded in fve Norwegian hospitals was investigated using image reports and medical records as gold standard. A relatively high completeness and correctness of the diagnoses was found. Algorithms used to define forearm fractures in administrative data should depend on study purpose.<p> <p>Purpose In Norway, forearm fractures are routinely recorded ...
